Broken bones will heal with the help of gene therapy and microbubbles


If the fracture of the damaged area is too large, you need to figure out how to “patch”. Traditionally to do this, take a piece of bone from another part of the body of the patient, and if the deformation is very large, then use the stimulants of bone growth. They have too many side effects – however, the new technology will help eliminate most problems.

For quick recovery bone perfect bone morphogenetic proteins, but they are poorly controlled. In high concentrations bones can start to grow directly in the soft tissues, so scientists would like to use the cells as a whole, but only part of their genes for rapid growth. But how to deliver this piece of the genetic code to the right address?

A new experimental method called “sonoporation” – using ultrasound in the lipid shell of gas-filled cells creates micro-bubbles, which push cellular protection, creating a hole. Once the genes are delivered inside, repeated ultrasound pulse destroys the bubbles and all is restored. The genes themselves can be obtained from stem cells, growing them in the right quantity.

The experiment on the broken bones of pigs showed that just one injection of genes into the bone tissue around the injury to 6-8 weeks it is completely healed is the same, but the new, grown-up cloth. The animals from the control group by the time the fractures have not even begun to scab. Before experiments on humans are still far, but the prospects are so fast and efficient treatment of fractures is very high.


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